0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Condensed Consolidated Statements of Operations (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Condensed Consolidated Statements of Changes in Convertible Preferred Stock and Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - The Company and Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Accrued and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Convertible Preferred Stock and Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Sale of Pegzilarginase to Immedica link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Accrued and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Related Party Transactions (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - The Company and Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Fair Value Measurements - Schedule of Fair Value of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Fair Value Measurements - Schedule of Significant Inputs Used to Estimate the Fair Value of CVR Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Fair Value Measurements - Schedule of Changes in CVR Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Estimated Fair Value of Cash Equivalents and Marketable Securities and Gross Unrealized Gains and Losses (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Available-for-Sale Securities in an Unrealized Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Cash Equivalents and Marketable Securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Contractual Maturities of Marketable Securities at Estimated Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Accrued and Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Licensing Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Related Party Transactions - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Related Party Transactions - Schedule of Expenses Related to Related Party Which are Settled in Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Convertible Preferred Stock and Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Stock-Based Compensation - Schedule of Stock Awards Granted Under all Equity Incentive and Inducement Plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Stock-Based Compensation - Schedule of Weighted-Average Assumptions Used in Calculating Fair Value of Awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Sale of Pegzilarginase to Immedica (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Segment Reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Segment Reporting - Schedule of Significant Expenses Provided to the CODM on a Regular Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Net Loss Per Share - Schedule of Weighted-Average Equity Instruments Excluded from Calculation of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink